In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with unidirectionally releasing microcontainers (MCs) has previously been shown to increase ins...

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Bibliographic Details
Main Authors: Jacob Rune Jørgensen, Feiyang Yu, Ramakrishnan Venkatasubramanian, Line Hagner Nielsen, Hanne Mørck Nielsen, Anja Boisen, Thomas Rades, Anette Müllertz
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
oral peptide delivery
microdevices
permeation enhancers
protease inhibitors
caco-2 cells
franz diffusion cells
oral gavage
Online Access:https://www.mdpi.com/1999-4923/12/1/48

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https://www.mdpi.com/1999-4923/12/1/48

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