Pharmacokinetic/Pharmacodynamic Analysis and Dose Optimization of Cefmetazole and Flomoxef against Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> in Patients with Invasive Urinary Tract Infection Considering Renal Function

Pharmacokinetic/Pharmacodynamic Analysis and Dose Optimization of Cefmetazole and Flomoxef against Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> in Patients with Invasive Urinary Tract Infection Considering Renal Function

The optimal regimens of cefmetazole and flomoxef for the treatment of urinary tract infections caused by extended-spectrum β-lactamase (ESBL)-producing <i>Enterobacterales</i> are not well defined. Our study found that the pharmacokinetic/pharmacodynamic targets for cefmetazole and flomo...

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Bibliographic Details
Main Authors: Yukihiro Hamada, Hidefumi Kasai, Moeko Suzuki-Ito, Yasufumi Matsumura, Yohei Doi, Kayoko Hayakawa
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
antimicrobial stewardship
cefmetazole
flomoxef
pharmacokinetics/pharmacodynamics
Monte Carlo simulations
Online Access:https://www.mdpi.com/2079-6382/11/4/456

Internet

https://www.mdpi.com/2079-6382/11/4/456

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