A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP

A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP

Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early...

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Bibliographic Details
Main Authors: Jessica J. Hobson, Zhijie Li, Hao Hu, Charles W. Carter
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
genetic coding
protein synthesis
mechanistic enzymology
protein engineering
evolutionary intermediates
validating weak catalytic activities
Online Access:https://www.mdpi.com/1422-0067/23/8/4229

Internet

https://www.mdpi.com/1422-0067/23/8/4229

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