Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition.

Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition.

Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as a therapeutic target in GBM due to their relative resi...

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Bibliographic Details
Main Authors: Mutsuko Minata, Chunyu Gu, Kaushal Joshi, Mariko Nakano-Okuno, Christopher Hong, Chi-Hung Nguyen, Harley I Kornblum, Annie Molla, Ichiro Nakano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3989164?pdf=render

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http://europepmc.org/articles/PMC3989164?pdf=render

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