α4/α9 Integrins Coordinate Epithelial Cell Migration Through Local Suppression of MAP Kinase Signaling Pathways

α4/α9 Integrins Coordinate Epithelial Cell Migration Through Local Suppression of MAP Kinase Signaling Pathways

Adhesion of basal keratinocytes to the underlying extracellular matrix (ECM) plays a key role in the control of skin homeostasis and response to injury. Integrin receptors indirectly link the ECM to the cell cytoskeleton through large protein complexes called focal adhesions (FA). FA also function a...

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Bibliographic Details
Main Authors: Willow Hight-Warburton, Robert Felix, Andrew Burton, Hannah Maple, Magda S. Chegkazi, Roberto A. Steiner, John A. McGrath, Maddy Parsons
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
integrin alpha4
integrin alpha9
MAP kinase
cell movement
actin cytoskeleton
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.750771/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.750771/full

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