Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model

Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model

The molecular mechanism of myeloid sarcoma (MS) formation remains nuclear. Our clinical and mouse model findings from a previous study revealed that cooperation of KMT2A (MLL) translocation (MLL-t) with activating N-/K-RAS mutations promoted MS formation in a shorter latency. To improve the understa...

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Bibliographic Details
Main Authors: Jen-Fen Fu, Chih-Jen Wen, Tzung-Hai Yen, Lee-Yung Shih
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MLL translocation
KRAS mutation
Hoxa11
Hoxa10
Myeloid sarcoma
Migration
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862200029X

Internet

http://www.sciencedirect.com/science/article/pii/S147655862200029X

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