Toward a Treatment of Cancer: Design and In Vitro/In Vivo Evaluation of Uncharged Pyrazoline Derivatives as a Series of Novel SHP2 Inhibitors

Toward a Treatment of Cancer: Design and In Vitro/In Vivo Evaluation of Uncharged Pyrazoline Derivatives as a Series of Novel SHP2 Inhibitors

Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase (PTP) encoded by the <i>PTPN11</i> gene, which is involved in the RAS/MAPK cell signaling transduction process. SHP2 has been shown to contribute to the progression of va...

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Bibliographic Details
Main Authors: Jiajia Dai, Yiting Zhang, Yanan Gao, Xiaoyi Bai, Fang Liu, Shuo Li, Yanyan Yu, Wenpeng Hu, Ting Shi, Dayong Shi, Xiangqian Li
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
anti-tumor
SHP2
inhibitor
apoptosis
toxicity
Online Access:https://www.mdpi.com/1422-0067/23/7/3497

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https://www.mdpi.com/1422-0067/23/7/3497

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