Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome

Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome

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22q11.2 deletion syndrome (22q11.2DS) is the most common human chromosomal microdeletion, causing developmentally linked congenital malformations, thymic hypoplasia, hypoparathyroidism, and/or cardiac defects. Thymic hypoplasia leads to T cell lymphopenia, which most often results in mild SCID. Desp...

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Bibliographic Details
Main Authors: Pratibha Bhalla, Qiumei Du, Ashwani Kumar, Chao Xing, Angela Moses, Igor Dozmorov, Christian A. Wysocki, Ondine B. Cleaver, Timothy J. Pirolli, Mary Louise Markert, Maria Teresa de la Morena, Antonio Baldini, Nicolai S.C. van Oers
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-07-01
Series:The Journal of Clinical Investigation
Subjects:
Genetics
Immunology
Online Access:https://doi.org/10.1172/JCI160101

Internet

https://doi.org/10.1172/JCI160101

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