eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.

BACKGROUND: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation. Considering this alternative chemistr...

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Bibliographic Details
Main Authors: Padmapriya Ponnuswamy, Angelika Schröttle, Eva Ostermeier, Sabine Grüner, Paul L Huang, Georg Ertl, Ulrich Hoffmann, Bernhard Nieswandt, Peter J Kuhlencordt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3264598?pdf=render

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http://europepmc.org/articles/PMC3264598?pdf=render

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