Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion

Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion

Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins function in all key steps of regulated secretion. Phase separation and amyloid-based storage of proteins and small molecules in secretory granules require ion homeostasis to maintain their steady states, and th...

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Bibliographic Details
Main Authors: Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang, Feng Qin, Paul Verkade, Michael X. Zhu, Qiu-Xing Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
regulated secretory pathways
cell surface anion channels
dimorphic CHGB
secretory granule exocytosis
cryo-EM structures
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1205516/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1205516/full

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