Fatal Necrotizing Encephalopathy after Treatment with Nivolumab for Squamous Non-Small Cell Lung Cancer: Case Report and Review of the Literature

Fatal Necrotizing Encephalopathy after Treatment with Nivolumab for Squamous Non-Small Cell Lung Cancer: Case Report and Review of the Literature

Immune checkpoint inhibitors are antibodies, which enhance cellular and humoral immune responses and are approved for the treatment of various tumors. Immune-related adverse events (irAE) involving different organs and systems are, however, among the side-effects. Recent reports of severe persistent...

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Bibliographic Details
Main Authors: Markus Leitinger, Mihael V. Varosanec, Slaven Pikija, Romana E. Wass, Dave Bandke, Serge Weis, Michael Studnicka, Susanne Grinzinger, Mark R. McCoy, Larissa Hauer, Johann Sellner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
neuroinflammation
neurodegeneration
encephalitis
immune checkpoint inhibitors
nivolumab
humoral and cellular immune response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00108/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00108/full

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