Progress to Clarify How <i>NOTCH3</i> Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease

Progress to Clarify How <i>NOTCH3</i> Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease

Notch signaling is conserved in <i>C. elegans</i>, <i>Drosophila</i>, and mammals. Among the four <i>NOTCH</i> genes in humans, <i>NOTCH1</i>, <i>NOTCH2</i>, and <i>NOTCH3</i> are known to cause monogenic hereditary disorders. M...

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Bibliographic Details
Main Authors: Ikuko Mizuta, Yumiko Nakao-Azuma, Hideki Yoshida, Masamitsu Yamaguchi, Toshiki Mizuno
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
Notch signaling
CADASIL
<i>NOTCH3</i>
EGF-like repeat
extracellular domain
granular osmiophilic material (GOM)
Online Access:https://www.mdpi.com/2218-273X/14/1/127

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https://www.mdpi.com/2218-273X/14/1/127

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