In Vivo and In Vitro Pro-Fibrotic Response of Lung-Resident Mesenchymal Stem Cells from Patients with Idiopathic Pulmonary Fibrosis

In Vivo and In Vitro Pro-Fibrotic Response of Lung-Resident Mesenchymal Stem Cells from Patients with Idiopathic Pulmonary Fibrosis

Lung-resident mesenchymal stem cells (LR-MSC) are thought to participate in idiopathic pulmonary fibrosis (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC in IPF patients present senescence-related features. It is unclear how they respond to a profibrotic environment. Here, we...

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Bibliographic Details
Main Authors: Gabriel Escarrer-Garau, Aina Martín-Medina, Joan Truyols-Vives, Cristina Gómez-Bellvert, Linda Elowsson, Gunilla Westergren-Thorsson, Maria Molina-Molina, Josep Mercader-Barceló, Ernest Sala-Llinàs
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
idiopathic pulmonary fibrosis
lung-resident mesenchymal stem cell
transforming growth factor β
bleomycin
inflammation
extracellular matrix proteins
Online Access:https://www.mdpi.com/2073-4409/13/2/160

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https://www.mdpi.com/2073-4409/13/2/160

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