The HLA class-II immunopeptidomes of AAV capsids proteins

The HLA class-II immunopeptidomes of AAV capsids proteins

IntroductionGene therapies are using Adeno-associated viruses (AAVs) as vectors, but immune responses against the capsids pose challenges to their efficiency and safety. Helper T cell recognition of capsid-derived peptides bound to human leukocyte antigen (HLA) class II molecules is an essential ste...

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Bibliographic Details
Main Authors: Carlos A. Brito-Sierra, Megan B. Lannan, Robert W. Siegel, Laurent P. Malherbe
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
AAV (Adeno-associated virus)
immunogenicity
immunopeptidome
gene therapy
risk assessment
CD4+
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1067399/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1067399/full

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