Pyruvate Dehydrogenase Kinase 4 Deficiency Increases Tumorigenesis in a Murine Model of Bladder Cancer

Pyruvate Dehydrogenase Kinase 4 Deficiency Increases Tumorigenesis in a Murine Model of Bladder Cancer

Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial isozyme in the PDK family (PDK1-4) partially responsible for phosphorylation of pyruvate dehydrogenase (PDH). Phosphorylation of PDH is thought to result in a pro-proliferative shift in metabolism that sustains growth of cancer cells. Previou...

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Bibliographic Details
Main Authors: Benjamin L. Woolbright, Ganeshkumar Rajendran, Erika Abbott, Austin Martin, Ryan Didde, Katie Dennis, Robert A. Harris, John A. Taylor
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
bladder cancer
mouse
PDK4
BBN
PDH
Online Access:https://www.mdpi.com/2072-6694/15/6/1654

Internet

https://www.mdpi.com/2072-6694/15/6/1654

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