Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome

Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome

Abstract Background Fragile X syndrome (FXS), the most common genetic cause of autism spectrum disorder and intellectual disability, is caused by the lack of fragile X mental retardation protein (FMRP) expression. FMRP is an mRNA binding protein with functions in mRNA transport, localization, and tr...

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Bibliographic Details
Main Authors: Magdalena Kalinowska, Mathijs B. van der Lei, Michael Kitiashvili, Maggie Mamcarz, Mauricio M. Oliveira, Francesco Longo, Eric Klann
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Molecular Autism
Subjects:
FMRP
Fragile X syndrome
Inhibitory neurons
Behavior
Autism
Protein synthesis
Online Access:https://doi.org/10.1186/s13229-022-00509-2

Internet

https://doi.org/10.1186/s13229-022-00509-2

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