Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Summary: The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and memory are still poorly explored. Astrocytes form large intercellular networks by gap junction coupling, mainly composed of two gap junction channel proteins, connexin 30 (Cx30) and connexin 43 (Cx43)....

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Bibliographic Details
Main Authors: Ladina Hösli, Noemi Binini, Kim David Ferrari, Laetitia Thieren, Zoe J. Looser, Marc Zuend, Henri S. Zanker, Stewart Berry, Martin Holub, Wiebke Möbius, Torben Ruhwedel, Klaus-Armin Nave, Christian Giaume, Bruno Weber, Aiman S. Saab
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Reports
Subjects:
astrocytes
gap junction coupling
connexin 30
connexin 43
astrocytic network
hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722002170

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http://www.sciencedirect.com/science/article/pii/S2211124722002170

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