Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer

Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer

Abstract Background The prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance to concurrent systemic therapy. Cancer-associated fibroblasts (CAFs), as essential participators in the tumor microenvironment (TME), play a vital role in...

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Bibliographic Details
Main Authors: Sheng Zheng, Jiafeng Wang, Ning Ding, Wenwen Chen, Hongda Chen, Meng Xue, Fei Chen, Jiaojiao Ni, Zhuo Wang, Zhenghua Lin, Haiping Jiang, Xiangrui Liu, Liangjing Wang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Nanobiotechnology
Subjects:
Gastric cancer
Cancer-associated fibroblasts
Tumor microenvironment
Polymeric prodrug
Triptolide
SN38
Online Access:https://doi.org/10.1186/s12951-021-01127-5

Internet

https://doi.org/10.1186/s12951-021-01127-5

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