Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways

Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways

Abstract Background Demyelinating diseases in central nervous system (CNS) are a group of diseases characterized by myelin damage or myelin loss. Transforming growth factor beta1 (TGF-β1) is widely recognized as an anti-inflammatory cytokine, which can be produced by both glial and neuronal cells in...

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Bibliographic Details
Main Authors: Yi Xie, Xuejiao Chen, Ying Li, Simiao Chen, Shuai Liu, Zhiyuan Yu, Wei Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Neuroinflammation
Subjects:
Demyelination
Cognitive deficit
LPC
TGF-β1
Microglia
Pyroptosis
Online Access:https://doi.org/10.1186/s12974-022-02557-0

Internet

https://doi.org/10.1186/s12974-022-02557-0

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