Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China
Introduction: The interactions between apolipoprotein E (APOE) genotype and diet pattern changes were found significant in several trials, implying that APOE gene may modify the effect of animal protein-rich food on health outcomes. We aim to study the interaction of APOE genotype with the effect of...
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.697389/full |
| _version_ | 1819145397894905856 |
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| author | Xurui Jin Xurui Jin Shangzhi Xiong Shangzhi Xiong Changzheng Yuan Enying Gong Xian Zhang Yao Yao Yu Leng Zhangming Niu Yi Zeng Yi Zeng Yi Zeng Lijing L. Yan Lijing L. Yan Lijing L. Yan Lijing L. Yan |
| author_facet | Xurui Jin Xurui Jin Shangzhi Xiong Shangzhi Xiong Changzheng Yuan Enying Gong Xian Zhang Yao Yao Yu Leng Zhangming Niu Yi Zeng Yi Zeng Yi Zeng Lijing L. Yan Lijing L. Yan Lijing L. Yan Lijing L. Yan |
| author_sort | Xurui Jin |
| collection | DOAJ |
| description | Introduction: The interactions between apolipoprotein E (APOE) genotype and diet pattern changes were found significant in several trials, implying that APOE gene may modify the effect of animal protein-rich food on health outcomes. We aim to study the interaction of APOE genotype with the effect of meat, fish and egg intake on mortality.Methods: This population-based study enrolled 8,506 older adults (mean age: 81.7 years, 52.3% female) from the Chinese Longitudinal Healthy Longevity Study. The intake frequency of meat, fish and egg was assessed by 3-point questions at baseline. Cox regression was conducted to calculate the hazard ratios for all-cause mortality of intake levels of meat, fish and egg. The analyses were stratified by APOE genotype and sex. The analyses were performed in 2020.Results: In the multivariable-adjusted models, meat and fish intake was associated with all-cause mortality (high vs. low intake: meat: HR: 1.14, 95% CI: 1.01, 1.28; fish: HR: 0.83, 95% CI: 0.73, 0.95). APOE genotype have significant interactions with meat and fish intake (Ps < 0.05). Compared with low fish intake, high fish intake was associated with lower risk of mortality (HR: 0.74, 95% CI: 0.56–0.98) only among the APOE ε4 carriers. High meat intake was significantly associated with higher risks of mortality (HR: 1.13, 95% CI: 1.04–1.25) only among the APOE ε4 non-carriers. The interactive relationship was restricted among the male. No significant findings were observed between egg and mortality among carriers or non-carriers.Conclusions: Among Chinese older adults, the significance of associations of mortality with reported meat or fish intake depended on APOE-E4 carriage status. If validated by other studies, our findings provide evidence for gene-based “precision” lifestyle recommendations. |
| first_indexed | 2024-12-22T12:57:23Z |
| format | Article |
| id | doaj.art-614f70a8f92f433885d0eff12405722b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-22T12:57:23Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-614f70a8f92f433885d0eff12405722b2022-12-21T18:25:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.697389697389Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in ChinaXurui Jin0Xurui Jin1Shangzhi Xiong2Shangzhi Xiong3Changzheng Yuan4Enying Gong5Xian Zhang6Yao Yao7Yu Leng8Zhangming Niu9Yi Zeng10Yi Zeng11Yi Zeng12Lijing L. Yan13Lijing L. Yan14Lijing L. Yan15Lijing L. Yan16Global Health Research Center, Duke Kunshan University, Kunshan, ChinaMindrank AI Ltd, Hangzhou, ChinaGlobal Health Research Center, Duke Kunshan University, Kunshan, ChinaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaDepartment of Big Data and Health Science, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaSchool of Population and Global Health, University of Melbourne, Melbourne, VIC, AustraliaMindrank AI Ltd, Hangzhou, ChinaCenter for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, ChinaGlobal Health Research Center, Duke Kunshan University, Kunshan, ChinaMindrank AI Ltd, Hangzhou, ChinaCenter for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, ChinaCenter for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC, United StatesDuke Global Health Institute, Duke University, Durham, NC, United StatesGlobal Health Research Center, Duke Kunshan University, Kunshan, ChinaDuke Global Health Institute, Duke University, Durham, NC, United StatesThe George Institute for Global Health, Beijing, China0Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesIntroduction: The interactions between apolipoprotein E (APOE) genotype and diet pattern changes were found significant in several trials, implying that APOE gene may modify the effect of animal protein-rich food on health outcomes. We aim to study the interaction of APOE genotype with the effect of meat, fish and egg intake on mortality.Methods: This population-based study enrolled 8,506 older adults (mean age: 81.7 years, 52.3% female) from the Chinese Longitudinal Healthy Longevity Study. The intake frequency of meat, fish and egg was assessed by 3-point questions at baseline. Cox regression was conducted to calculate the hazard ratios for all-cause mortality of intake levels of meat, fish and egg. The analyses were stratified by APOE genotype and sex. The analyses were performed in 2020.Results: In the multivariable-adjusted models, meat and fish intake was associated with all-cause mortality (high vs. low intake: meat: HR: 1.14, 95% CI: 1.01, 1.28; fish: HR: 0.83, 95% CI: 0.73, 0.95). APOE genotype have significant interactions with meat and fish intake (Ps < 0.05). Compared with low fish intake, high fish intake was associated with lower risk of mortality (HR: 0.74, 95% CI: 0.56–0.98) only among the APOE ε4 carriers. High meat intake was significantly associated with higher risks of mortality (HR: 1.13, 95% CI: 1.04–1.25) only among the APOE ε4 non-carriers. The interactive relationship was restricted among the male. No significant findings were observed between egg and mortality among carriers or non-carriers.Conclusions: Among Chinese older adults, the significance of associations of mortality with reported meat or fish intake depended on APOE-E4 carriage status. If validated by other studies, our findings provide evidence for gene-based “precision” lifestyle recommendations.https://www.frontiersin.org/articles/10.3389/fmed.2021.697389/fullAPOE genotypehealthy agingChinese older adultsdietlongitudinal study |
| spellingShingle | Xurui Jin Xurui Jin Shangzhi Xiong Shangzhi Xiong Changzheng Yuan Enying Gong Xian Zhang Yao Yao Yu Leng Zhangming Niu Yi Zeng Yi Zeng Yi Zeng Lijing L. Yan Lijing L. Yan Lijing L. Yan Lijing L. Yan Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China Frontiers in Medicine APOE genotype healthy aging Chinese older adults diet longitudinal study |
| title | Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China |
| title_full | Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China |
| title_fullStr | Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China |
| title_full_unstemmed | Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China |
| title_short | Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China |
| title_sort | apolipoprotein e genotype meat fish and egg intake in relation to mortality among older adults a longitudinal analysis in china |
| topic | APOE genotype healthy aging Chinese older adults diet longitudinal study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.697389/full |
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