The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm

The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm

The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function. It is mainly activated by the steroid progesterone (P4) but is also promiscuously activated by a wide range of synthetic and physiologic...

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Bibliographic Details
Main Authors: Lydia Wehrli, Ioannis Galdadas, Lionel Voirol, Martin Smieško, Yves Cambet, Vincent Jaquet, Stéphane Guerrier, Francesco Luigi Gervasio, Serge Nef, Rita Rahban
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CatSper
steroids
human sperm
high-throughput screening
calcium signaling
pharmacophore modelling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1221578/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1221578/full

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