PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck s...

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Bibliographic Details
Main Authors: Megan Morisada, Paul E. Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W. Hodge, James B. Mitchell, Jay Friedman, Clint T. Allen
Format: Article
Language:English
Published: Taylor & Francis Group 2018-03-01
Series:OncoImmunology
Subjects:
radiation
resistance
checkpoint
immunity
abscopal
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1395996

Internet

http://dx.doi.org/10.1080/2162402X.2017.1395996

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