Integrated metabolomics and transcriptomics to reveal biomarkers and mitochondrial metabolic dysregulation of premature ovarian insufficiency

Integrated metabolomics and transcriptomics to reveal biomarkers and mitochondrial metabolic dysregulation of premature ovarian insufficiency

BackgroundThe metabolic characteristics of premature ovarian insufficiency (POI), a reproductive endocrine disease characterized by abnormal sex hormone metabolism and follicle depletion, remain unclear. Metabolomics is a powerful tool for exploring disease phenotypes and biomarkers. This study aims...

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Bibliographic Details
Main Authors: Zhaoyang Yu, Weilong Peng, Feiwen Li, Xiaoqian Fu, Jiajia Wang, Hongfan Ding, Mujun Li, Huimei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Endocrinology
Subjects:
premature ovarian insufficiency
metabolomics
transcriptomics
biomarkers
machine learning
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1280248/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1280248/full

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