Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation

Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation

We previously showed that N6L, a pseudopeptide that targets nucleolin, impairs pancreatic ductal adenocarcinoma (PDAC) growth and normalizes tumor vessels in animal models. In this study, we analyzed the translatome of PDAC cells treated with N6L to identify the pathways that were either repressed o...

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Bibliographic Details
Main Authors: Mounira Chalabi-Dchar, Elisabeth Cruz, Hichem C. Mertani, Jean-Jacques Diaz, José Courty, Ilaria Cascone, Philippe Bouvet
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
nucleolin
pancreatic cancer
translation
mTOR inhibitor
combotherapy
Online Access:https://www.mdpi.com/2072-6694/13/19/4957

Internet

https://www.mdpi.com/2072-6694/13/19/4957

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