Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding angiotensin receptor shRNA

Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding angiotensin receptor shRNA

Elevated brain angiotensin II activity plays a key role in the development of neurogenic hypertension. While blood pressure (BP) control in neurogenic hypertension has been successfully demonstrated by regulating central angiotensin II activity, current techniques involving cerebrovascular injection...

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Bibliographic Details
Main Authors: Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
Neurogenic hypertension
brain-targeted
gene delivery
functionalized liposomes
plasmid DNA encoding shRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124000970

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http://www.sciencedirect.com/science/article/pii/S2162253124000970

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