An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats

Aim: Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy that results in death from right ventricular failure (RVF). There is limited understanding of the molecular mechanisms of RVF in PAH.Methods: In a PAH-RVF model induced by injection of adult male rats with monocrotal...

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Bibliographic Details
Main Authors: Charles Colin Thomas Hindmarch, Lian Tian, Ping Yu Xiong, Francois Potus, Rachel Emily Teresa Bentley, Ruaa Al-Qazazi, Kurt W. Prins, Stephen L. Archer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.966454/full