MFG-E8 Maintains Cellular Homeostasis by Suppressing Endoplasmic Reticulum Stress in Pancreatic Exocrine Acinar Cells

MFG-E8 Maintains Cellular Homeostasis by Suppressing Endoplasmic Reticulum Stress in Pancreatic Exocrine Acinar Cells

Excessive endoplasmic reticulum (ER) stress contributes significantly to the pathogenesis of exocrine acinar damage in acute pancreatitis. Our previous study found that milk fat globule EGF factor 8 (MFG-E8), a lipophilic glycoprotein, alleviates acinar cell damage during AP via binding to αvβ3/5 in...

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Bibliographic Details
Main Authors: Yifan Ren, Wuming Liu, Jia Zhang, Jianbin Bi, Meng Fan, Yi Lv, Zheng Wu, Yuanyuan Zhang, Rongqian Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pancreatic exocrine acinar cells
endoplasmic reticulum stress
acute pancreatitis
MFG-E8
αvβ3/5 integrins
FAK-STAT3 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.803876/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.803876/full

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