The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease

The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease

Leucine-rich repeat kinase 2 (LRRK2) is one of the most common causative genes in Parkinson’s disease (PD). The complex structure of this multiple domains’ protein determines its versatile functions in multiple physiological processes, including migration, autophagy, phagocytosis, and mitochondrial...

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Bibliographic Details
Main Authors: Mengfei Zhang, Chaoyi Li, Jie Ren, Huakun Wang, Fang Yi, Junjiao Wu, Yu Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
LRRK2
neuroinflammation
microglia
immune function
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.909303/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.909303/full

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