The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage

The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage

ABSTRACTClostridioides difficile is a Gram-positive, anaerobic, spore-forming bacterium responsible for antibiotic-associated pseudomembranous colitis. Clostridioides difficile infection (CDI) symptoms can range from diarrhea to life-threatening colon damage. Toxins produced by C. difficile (TcdA an...

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Bibliographic Details
Main Authors: Sweta Ghosh, Daniel Erickson, Michelle J. Chua, James Collins, Venkatakrishna Rao Jala
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSystems
Subjects:
Clostridioides difficile
urolithin A
toxin production
gut barrier function
colitis
Online Access:https://journals.asm.org/doi/10.1128/msystems.01255-23

Internet

https://journals.asm.org/doi/10.1128/msystems.01255-23

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