2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway.

2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway.

2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneall...

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Bibliographic Details
Main Authors: Zhemin Wang, Zewen Qiu, Chenxue Gao, Yijie Sun, Wei Dong, Yan Zhang, Ruolin Chen, Yuan Qi, Shuangyue Li, Yanjie Guo, Yongjun Piao, Sheng Li, Fengyuan Piao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5487034?pdf=render

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http://europepmc.org/articles/PMC5487034?pdf=render

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