LINC00540 promotes sorafenib resistance and functions as a ceRNA for miR-4677-3p to regulate AKR1C2 in hepatocellular carcinoma

LINC00540 promotes sorafenib resistance and functions as a ceRNA for miR-4677-3p to regulate AKR1C2 in hepatocellular carcinoma

Sorafenib resistance is one of the main causes of poor prognosis in patients with advanced hepatocellular carcinoma (HCC). Long noncoding RNAs (lncRNAs) function as suppressors or oncogenic factors during tumor progression and drug resistance. Here, to identify therapeutic targets for HCC, the biolo...

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Bibliographic Details
Main Authors: Kaixuan Xu, Xinxin Wang, Shuwei Hu, Jiaxuan Tang, Shihui Liu, Hui Chen, Xiaobin Zhang, Penggao Dai
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Hepatocellular carcinoma
Sorafenib resistance
LINC00540
lncRNAs
ceRNA
AKR1C2
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402403353X

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http://www.sciencedirect.com/science/article/pii/S240584402403353X

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