HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and are Commonly Detected in Plasma from HIV-infected Humans

HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and are Commonly Detected in Plasma from HIV-infected Humans

HIV-specific antibodies (Abs) can reduce viral burden by blocking new rounds of infection or by destroying infected cells via activation of effector cells through Fc–FcR interaction. This latter process, referred to as antibody-dependent cellular cytotoxicity (ADCC), has been associated with viral c...

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Bibliographic Details
Main Authors: Katherine L. Williams, Valerie Cortez, Adam S. Dingens, Johannes S. Gach, Stephanie Rainwater, Julie F. Weis, Xuemin Chen, Paul Spearman, Donald N. Forthal, Julie Overbaugh
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:EBioMedicine
Subjects:
ADCC
RF-ADCC
Antibody
HIV
CD4-induced
CD4i
C11
Potency
Breadth
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301237

Internet

http://www.sciencedirect.com/science/article/pii/S2352396415301237

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