Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain MRGPRX2 agoni...

Full description

Bibliographic Details
Main Authors: Chalatip Chompunud Na Ayudhya, Aetas Amponnawarat, Hydar Ali
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
mast cells
MRGPRX2
MrgprB2
tyrosine
substance P
signaling
Online Access:https://www.mdpi.com/1422-0067/22/10/5318

Internet

https://www.mdpi.com/1422-0067/22/10/5318

Similar Items