Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins

Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins

C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. After 8 weeks treatment, mice with dilated cardiomyopathy developed serious cardiac dysfunction characterized by significantly enhanced left ventricular end-diastol...

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Bibliographic Details
Main Authors: Hu Wei, Jiang Wen-Bing
Format: Article
Language:English
Published: Sciendo 2014-03-01
Series:Acta Pharmaceutica
Subjects:
pitavastatin
dilated cardiomyopathy
calcium handling proteins
renin-angiotensin system
protein kinase Cβ2
Online Access:http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0004/acph-2014-0004.xml?format=INT

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http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0004/acph-2014-0004.xml?format=INT

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