Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A

Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A

The cell-autonomous effect of five severe loss- or gain-of-function GluN2A (NMDA receptor) mutations is assessed on evoked NMDAR-mediated synaptic currents in CA1 pyramidal neurons in cultured mouse hippocampal slices. Data and modelling suggest that mutant-like NMDA-EPSCs can lead to abnormal tempo...

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Bibliographic Details
Main Authors: Marwa Elmasri, Daniel William Hunter, Giles Winchester, Ella Emine Bates, Wajeeha Aziz, Does Moolenaar Van Der Does, Eirini Karachaliou, Kenji Sakimura, Andrew. Charles Penn
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03115-3

Internet

https://doi.org/10.1038/s42003-022-03115-3

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