The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

<p>Abstract</p> <p>Background</p> <p>The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA hybrid is created whose RNA...

Full description

Bibliographic Details
Main Authors: Leo Berit, Schweimer Kristian, Rösch Paul, Hartl Maximilian J, Wöhrl Birgitta M
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Retrovirology
Subjects:
Foamy virus
Retroviral RNase H
C-helix
Basic loop
NMR
Basic protrusion
Solution structure
Substrate binding
Online Access:http://www.retrovirology.com/content/9/1/73

Internet

http://www.retrovirology.com/content/9/1/73

Similar Items