Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

Abstract The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. Although the structure of polymerase is well understood, our knowledge of its regula...

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Detaylı Bibliyografya
Asıl Yazarlar: Lu Liu, Ramakanth Madhugiri, Vera Vivian Saul, Susanne Bacher, Michael Kracht, Stephan Pleschka, M. Lienhard Schmitz
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Nature Portfolio 2023-04-01
Seri Bilgileri:Scientific Reports
Online Erişim:https://doi.org/10.1038/s41598-023-34285-7

Internet

https://doi.org/10.1038/s41598-023-34285-7

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