Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism.

Bibliographic Details
Main Authors: Karthik Sathiyamoorthy, Yao Xiong Hu, Britta S. Möhl, Jia Chen, Richard Longnecker, Theodore S. Jardetzky
Format: Article
Language:English
Published: Nature Portfolio 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13557