Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1

Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1

Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies. Methods: Electrophysiological measurements were used for monitoring functional changes in the diarrheic colon spec...

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Bibliographic Details
Main Authors: Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
irritable bowel syndrome
intestinal barrier function
tight junctions
claudin-1
tricellulin
leaky gut
Online Access:https://www.mdpi.com/2073-4409/12/24/2846

Internet

https://www.mdpi.com/2073-4409/12/24/2846

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