Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism

Summary: Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested wheth...

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Main Authors: Michelle C.D. Bridi, Nancy Luo, Grace Kim, Benjamin J. Menarchek, Rachel A. Lee, Bryan Rodriguez, Daniel Severin, Christian Wesselborg, Caroline O’Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood, Cristian Moreno, Altagracia Contreras
格式: 文件
语言:English
出版: Elsevier 2025-01-01
丛编:iScience
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在线阅读:http://www.sciencedirect.com/science/article/pii/S2589004224027214