Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse

Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse

Over the last decade, a large variety of alterations of the Contactin Associated Protein 2 (CNTNAP2) gene, encoding Caspr2, have been identified in several neuronal disorders, including neurodevelopmental disorders and peripheral neuropathies. Some of these alterations are homozygous but most are he...

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Bibliographic Details
Main Authors: Carmen Cifuentes-Diaz, Giorgia Canali, Marta Garcia, Mélanie Druart, Taylor Manett, Mythili Savariradjane, Camille Guillaume, Corentin Le Magueresse, Laurence Goutebroze
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
Caspr2
corpus callosum
anterior commissure
sciatic nerve
axon diameter
myelin thickness
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1100121/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1100121/full

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