PARP Inhibitors and Haematological Malignancies—Friend or Foe?

Since their introduction several years ago, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have become the standard of care for breast and gynaecological cancers with <i>BRCA</i> gene mutations. Given that PARPi act by exploiting defective DNA repair mechanisms within tumour cell...

Full description

Bibliographic Details
Main Authors: Kathryn A. Skelding, Lisa F. Lincz
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/21/5328