The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells

The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells

Background: Huntington's disease is an inherited progressive neurodegenerative disorder caused by an expansion of the polyglutamine tract leading to malformation and aggregation of the mutant huntingtin protein in the cell cytoplasm and nucleus of affected brain regions. The development of neur...

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Bibliographic Details
Main Authors: Azza Ramadan, Abuelnor Mohammed, Asim Ahmed Elnour, Adel Sadeq, Nadia Al Mazrouei, Maisoun Alkaabi, Khalid Awad Al-Kubaisi, Semira Abdi Beshir, Vineetha Menon, Abdulla AlAmoodi, Kishore Ganana Sam, Ali Awadallah Ali Mohamed Saeed, Sami Fatehi Abdalla, Samah Mohammed Hussein
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Aggregation
Huntington’s disease
Luteolin, misfolded protein
Neurodegenerative diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423003663

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http://www.sciencedirect.com/science/article/pii/S1319016423003663

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