Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages

Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages

Atherosclerotic plaques develop from the accumulation of macrophage-derived foam cells via the uptake of modified low-density lipoprotein (LDL). CD36 and CD204 are the principal scavenger receptors responsible for the uptake of modified LDL. Although glucocorticoids are suspected to exacerbate ather...

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Bibliographic Details
Main Authors: Ryota Hashimoto, Hiroshi Koide, Youichi Katoh
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Atherosclerosis
Glucocorticoids
Scavenger receptors
Uptake of modified LDL
MAPK pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S134786132200086X

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http://www.sciencedirect.com/science/article/pii/S134786132200086X

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