Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compoun...

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Bibliographic Details
Main Authors: M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone, Sharuk L. Khan
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
DHFR
antifungal
antibacterial
pyrimidines
benzimidazoles
ADMETlab 2.0
Online Access:https://www.mdpi.com/1420-3049/28/2/501

Internet

https://www.mdpi.com/1420-3049/28/2/501

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