Coevolutionary Analysis Implicates Toll-Like Receptor 9 in Papillomavirus Restriction

Coevolutionary Analysis Implicates Toll-Like Receptor 9 in Papillomavirus Restriction

ABSTRACT Upon infection, DNA viruses can be sensed by pattern recognition receptors (PRRs), leading to the activation of type I and III interferons to block infection. Therefore, viruses must inhibit these signaling pathways, avoid being detected, or both. Papillomavirus virions are trafficked from...

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Bibliographic Details
Main Authors: Kelly King, Brendan B. Larsen, Sophie Gryseels, Cécile Richet, Simona Kraberger, Robert Jackson, Michael Worobey, Joseph S. Harrison, Arvind Varsani, Koenraad Van Doorslaer
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
Mexican free-tailed bat
Papillomaviridae
TLR9
evolutionary biology
innate immunity
papillomavirus
Online Access:https://journals.asm.org/doi/10.1128/mbio.00054-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00054-22

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