HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1

Abstract RNA interference (RNAi) is a conserved gene silencing process that exists in diverse organisms to protect genome integrity and regulate gene expression. In C. elegans, the majority of RNAi pathway proteins localize to perinuclear, phase-separated germ granules, which are comprised of sub-do...

Full description

Bibliographic Details
Main Authors: Shihui Chen, Carolyn M. Phillips
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45245-8