Exploring the Correlation Between Fibrosis Biomarkers and Clinical Disease Severity in PLN p.Arg14del Patients

Exploring the Correlation Between Fibrosis Biomarkers and Clinical Disease Severity in PLN p.Arg14del Patients

Background: Pathogenic variants in phospholamban (PLN, like p. Arg14del), are found in patients diagnosed with arrhythmogenic (ACM) and dilated cardiomyopathy (DCM). Fibrosis formation in the heart is one of the hallmarks in PLN p.Arg14del carriers. During collagen synthesis and breakdown, propeptid...

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Bibliographic Details
Main Authors: Stephanie M. van der Voorn, Mimount Bourfiss, Anneline S. J. M. te Riele, Karim Taha, Marc A. Vos, Remco de Brouwer, Tom E. Verstraelen, Rudolf A. de Boer, Carol Ann Remme, Toon A. B. van Veen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
biomarkers
fibrosis
phospholamban (PLN)
cardiomyopathy
collagen
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.802998/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.802998/full

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