Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry

Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry

Abstract The bioorthogonal tetrazine-triggered cleavage of trans-cyclooctene(TCO)-linked payloads has strong potential for widespread use in drug delivery and in particular in click-cleavable antibody-drug conjugates (ADCs). However, clinical translation is hampered by an inverse correlation between...

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Bibliographic Details
Main Authors: Ron M. Versteegen, Raffaella Rossin, Ivo A. W. Filot, Freek J. M. Hoeben, Arthur H. A. M. van Onzen, Henk M. Janssen, Marc S. Robillard
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01392-z

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https://doi.org/10.1038/s42004-024-01392-z

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