Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.

Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.

Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca(2+) influx, perturbations of membrane conductivity, severe swelling and the formation of giant membr...

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Bibliographic Details
Main Authors: José M Molina-Guijarro, Álvaro Macías, Carolina García, Eva Muñoz, Luis F García-Fernández, Miren David, Lucía Núñez, Juan F Martínez-Leal, Victoria Moneo, Carmen Cuevas, M Pilar Lillo, Carlos Villalobos Jorge, Carmen Valenzuela, Carlos M Galmarini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3083409?pdf=render

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http://europepmc.org/articles/PMC3083409?pdf=render

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